Armchair Expert with Dax Shepard
Armchair Expert with Dax Shepard

Colleen Cutcliffe (on the microbiome)

Feb 18, 2026 · 2h 1m

<p>Colleen Cutcliffe (Pendulum Therapeutics) is a doctor of biochemistry and microbiology and CEO and co-founder of Pendulum Therapeutics. Colleen joins the Armchair Expert to discuss starting a microbiome supplement company inspired by her premature daughter who had to take antibiotics, applying hyenas' evolved ability to digest rotting meat to study gut bacteria, and how fecal transplants reliably help treat C. diff. Colleen and Dax talk about the real linkages between microbiome and depression, obesity, and more, how the body’s natural …

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