The Gist
Mike Pesca on Lifelong: The Bliss Molecule and the Psychology of Weight Loss
Mar 07, 2026
· 40m
<p>For this Saturday Show, Mike takes the guest seat on <em>Lifelong with Ethan Suplee</em>. Actor Ethan Suplee (<em>Remember the Titans</em>, <em>My Name Is Earl</em>) is well-known for his incredible physical transformation, having lost hundreds of pounds. Together, he and Mike get into a deep, candid discussion about the lifelong psychology of weight management, the economic politics of GLP-1 drugs, and why the extremes of the "Healthy at Every Size" movement veer into anti-science cultism. Plus, Mike reveals his biological "bliss …
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