5.2a Microcytic Anemias

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• Speaker 1 0:00
• Speaker 2 3:17

1. 0:00

   Peatükk 1: The first of the anemias that we're going to discuss are microcytic anemias. 197s · Speaker 1

   The first of the anemias that we're going to discuss are microcytic anemias. In a microcytic anemia, the red blood cells are small. And this size is actually measured by the MCV, or the mean corpuscular volume. And so the MCV in a microcyti…

2. 3:17

   Peatükk 2: Alright, and you know that heme is essentially composed of iron. 301s · Speaker 2

   Alright, and you know that heme is essentially composed of iron. plus protoporphyrin, just gonna say proto here, P -R -O -T -O, then if you understand this basic biochemistry, it's not hard to recognize the causes of microcytic anemia. For …

3. 8:18

   Peatükk 3: physiologically, the human body does not really have a way of getting rid of iron. 303s · Speaker 1

   physiologically, the human body does not really have a way of getting rid of iron. And so you only want to bring in iron when it's needed by the body, and you don't want to allow excess iron to come into the body. And so the enterocyte play…

4. 13:22

   Peatükk 4: causes of iron deficiency, again because of the blood loss associated with hookworms, these are common causes of iron deficiency in the developing world. 180s · Speaker 1

   causes of iron deficiency, again because of the blood loss associated with hookworms, these are common causes of iron deficiency in the developing world. There are some other causes to be aware of. Obviously, malnutrition could result in ir…

5. 16:22

   Peatükk 5: correct? because the storage iron is being consumed. 301s · Speaker 2

   correct? because the storage iron is being consumed. And as the serum ferritin goes down, one of the other things to bear in mind is that sort of always opposite of what ferritin does is TIBC. So whenever the ferritin goes down, the total i…

6. 21:23

   Peatükk 6: Now, let's go through and remind ourselves of a couple clinical features of iron deficiency. 300s · Speaker 1

   Now, let's go through and remind ourselves of a couple clinical features of iron deficiency. Obviously, the patients will become anemic. Another finding, clinically, would be that the patients would have koelonychia, which is sort of spoon …

7. 26:24

   Peatükk 7: you need to treat that as well. 99s · Speaker 1

   you need to treat that as well. So, for example, if there's an older male and he has iron deficiency anemia, it's very important to rule out colonic... carcinoma in that patient. So we don't simply just sort of figure out that there's an ir…