5.3 Macrocytic Anemia

Reproduktory

• Speaker 1 0:00
• Speaker 2 0:10
• Speaker 3 1:02
• Speaker 4 3:14
• Speaker 5 5:17

1. 0:00

   Kapitola 1: The next section that we want to discuss concerns macrocytic anemia. 61s · Speaker 1

   The next section that we want to discuss concerns macrocytic anemia. Now, in macrocytic anemia, the idea is that the patient develops an anemia, however, the red blood cells are relatively bigger than normal. Recall that the normal MCV is a…

2. 1:02

   Kapitola 2: Now, in a microcytic anemia, it's as if an extra division occurs, making the cells just a little bit smaller than usual. 131s · Speaker 3

   Now, in a microcytic anemia, it's as if an extra division occurs, making the cells just a little bit smaller than usual. Well, in a macrocytic anemia, it's as if one less division occurs, and when one less division occurs, the cells are goi…

3. 3:14

   Kapitola 3: it needs to lose this methyl group. 122s · Speaker 4

   it needs to lose this methyl group. And so very quickly, folate will basically convince vitamin B12 to take the methyl group. And so vitamin B12 will actually take this methyl group. Tetrahydrofolate will lose the methyl group, allowing tet…

4. 5:17

   Kapitola 4: anemia. And it's called a megaloblastic anemia because folate and vitamin B12 are obviously important for DNA, for synthesis of DNA precursors. 133s · Speaker 5

   anemia. And it's called a megaloblastic anemia because folate and vitamin B12 are obviously important for DNA, for synthesis of DNA precursors. And if we can't produce DNA precursors appropriately, not only will the red blood cells be affec…

5. 7:30

   Kapitola 5: two, three, four, five, six, seven lobes, and again, anything greater than five is abnormal. 301s · Speaker 2

   two, three, four, five, six, seven lobes, and again, anything greater than five is abnormal. In addition, you'll notice that most of these red blood cells are relatively normal in size, but you can see that there's a large red blood cell he…

6. 12:32

   Kapitola 6: it is important to know. 81s · Speaker 1

   it is important to know. The final clinical laboratory finding is actually a negative finding, but it's a helpful finding, and that is that the methylmalonic acid levels will be normal. Now, methylmalonic acid gets converted to succinyl -Co…

7. 13:54

   Kapitola 7: meat or eggs, and it comes into the body attached to those animal -derived proteins. 300s · Speaker 5

   meat or eggs, and it comes into the body attached to those animal -derived proteins. Once it comes into the body, however, vitamin B12 will be cleaved from those animal proteins and will be bound by a protein called R -binder. Now, our bind…

8. 18:55

   Kapitola 8: A third cause that I've listed here is dietary deficiency. 182s · Speaker 1

   A third cause that I've listed here is dietary deficiency. Recall, and I would like to really hit home on this point because, again, examiners like to go after it, it's very rare to see dietary deficiency except in vegans. And what are vega…