Anaemia #4
Jun 19, 2026 16:18
· 4:12
· English
· Whisper Turbo
· 2 speakers
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Speaker 2 (Anaemia #4)
So what are the physiological compensatory mechanisms in anemia?
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Hypoxia triggers these compensatory effects.
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Pasteur's effects.
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So a decrease in glycolysis rates and
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suppression of lactate accumulation in the presence of oxygen.
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Both effects.
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which is a decrease in affinity for hemoglobin.
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Of hemoglobin for oxygen caused by increased CO2,
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which allows more oxygen to unload to the tissues.
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Increased to 3dpg,
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it controls the ease of hemoglobin releasing to the
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tissues.
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So an increase in 2 ,3dpg is
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a decrease in oxygen.
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Affinity,
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meaning there is more oxygen that is delivered.
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Increase in cardiac output.
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Hyperdynamic circulation compensates for reduced oxygen
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carrying capacity.
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And then increased erythropoietin production,
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which stimulates erythropoietin.
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These adaptations allow the body to tolerate gradual
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severe anemia by prioritizing oxygen delivery to the brain.
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Then the next question that we are going
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to have.
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is laboratory investigations for anemia the essential
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tests include full blood counts with red cell indices peripheral
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blood smear and reticulocyte count now the red
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cell indices in question include mean corpuscular volume of
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80 to 100 ventilator which classifies the size whether
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is micro is 27 to
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33 picoliter which gives us the color and
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then image
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which is from 30 to 35 gram per day which shows
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hypochromia inflow then the reticulocyte counts so
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the corrected retics is the retic percentage times the
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patient's hematocritic concentration over normal
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the normal value is 0 .5 percent to 1
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.5 there is reticulocytosis you can
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think of this is sickle cell anemia autoimmune
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immune acute blood loss when it
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is less than think of i can
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see
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The indicators of transfusion.
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There is indication for blood transfusion.
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We have severe anemia with cardiovascular decompensation.
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Acute or severe blood loss.
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Bone marrow failure.
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Acute severe hemolysis.
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And one amount of blood increased purity from 3 to 5%.
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It's ferrous
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sulfate of 200mg.
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6 .5.
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Ferrous clopin of 300mg.
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6 .5.
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So there's an expected rise of 2g per day for every 3 weeks.
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Cosmophar,
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Pharynget,
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Ferrahim,
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Minofa is ferric hydroxide,
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sucrose.
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Cosmophar is iron dextran.
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Pharynget is ferric carboxyl,
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maltose.
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And Ferrahim is ferroxytol.
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and the indication is chronic renal failure with erythropoietin
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therapy.
This transcript was generated by AI (automatic speech recognition). May contain errors — verify against the original audio for critical use. AI policy
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