Anaemia #4
Jun 19, 2026 16:18
· 4:12
· English
· Whisper Turbo
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Speaker 2 (Anaemia #4)
So what are the physiological compensatory mechanisms in anemia?
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Speaker 2 (Anaemia #4)
Hypoxia triggers these compensatory effects.
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Speaker 2 (Anaemia #4)
Pasteur's effects.
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Speaker 2 (Anaemia #4)
So a decrease in glycolysis rates and
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Speaker 2 (Anaemia #4)
suppression of lactate accumulation in the presence of oxygen.
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Speaker 1 (Anaemia #4)
Both effects.
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Speaker 2 (Anaemia #4)
which is a decrease in affinity for hemoglobin.
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Speaker 2 (Anaemia #4)
Of hemoglobin for oxygen caused by increased CO2,
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Speaker 2 (Anaemia #4)
which allows more oxygen to unload to the tissues.
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Speaker 2 (Anaemia #4)
Increased to 3dpg,
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Speaker 2 (Anaemia #4)
it controls the ease of hemoglobin releasing to the
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Speaker 1 (Anaemia #4)
tissues.
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Speaker 2 (Anaemia #4)
So an increase in 2 ,3dpg is
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Speaker 2 (Anaemia #4)
a decrease in oxygen.
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Speaker 1 (Anaemia #4)
Affinity,
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Speaker 2 (Anaemia #4)
meaning there is more oxygen that is delivered.
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Speaker 2 (Anaemia #4)
Increase in cardiac output.
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Speaker 2 (Anaemia #4)
Hyperdynamic circulation compensates for reduced oxygen
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Speaker 2 (Anaemia #4)
carrying capacity.
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Speaker 2 (Anaemia #4)
And then increased erythropoietin production,
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Speaker 2 (Anaemia #4)
which stimulates erythropoietin.
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Speaker 2 (Anaemia #4)
These adaptations allow the body to tolerate gradual
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Speaker 2 (Anaemia #4)
severe anemia by prioritizing oxygen delivery to the brain.
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Speaker 2 (Anaemia #4)
Then the next question that we are going
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Speaker 1 (Anaemia #4)
to have.
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Speaker 2 (Anaemia #4)
is laboratory investigations for anemia the essential
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Speaker 2 (Anaemia #4)
tests include full blood counts with red cell indices peripheral
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Speaker 2 (Anaemia #4)
blood smear and reticulocyte count now the red
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Speaker 2 (Anaemia #4)
cell indices in question include mean corpuscular volume of
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Speaker 2 (Anaemia #4)
80 to 100 ventilator which classifies the size whether
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Speaker 2 (Anaemia #4)
is micro is 27 to
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Speaker 2 (Anaemia #4)
33 picoliter which gives us the color and
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Speaker 1 (Anaemia #4)
then image
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Speaker 2 (Anaemia #4)
which is from 30 to 35 gram per day which shows
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Speaker 2 (Anaemia #4)
hypochromia inflow then the reticulocyte counts so
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Speaker 2 (Anaemia #4)
the corrected retics is the retic percentage times the
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Speaker 2 (Anaemia #4)
patient's hematocritic concentration over normal
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Speaker 2 (Anaemia #4)
the normal value is 0 .5 percent to 1
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Speaker 2 (Anaemia #4)
.5 there is reticulocytosis you can
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Speaker 2 (Anaemia #4)
think of this is sickle cell anemia autoimmune
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Speaker 2 (Anaemia #4)
immune acute blood loss when it
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Speaker 2 (Anaemia #4)
is less than think of i can
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Speaker 1 (Anaemia #4)
see
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Speaker 2 (Anaemia #4)
The indicators of transfusion.
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Speaker 2 (Anaemia #4)
There is indication for blood transfusion.
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Speaker 2 (Anaemia #4)
We have severe anemia with cardiovascular decompensation.
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Speaker 2 (Anaemia #4)
Acute or severe blood loss.
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Speaker 1 (Anaemia #4)
Bone marrow failure.
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Speaker 2 (Anaemia #4)
Acute severe hemolysis.
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Speaker 2 (Anaemia #4)
And one amount of blood increased purity from 3 to 5%.
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Speaker 1 (Anaemia #4)
It's ferrous
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Speaker 2 (Anaemia #4)
sulfate of 200mg.
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Speaker 1 (Anaemia #4)
6 .5.
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Speaker 2 (Anaemia #4)
Ferrous clopin of 300mg.
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Speaker 1 (Anaemia #4)
6 .5.
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Speaker 2 (Anaemia #4)
So there's an expected rise of 2g per day for every 3 weeks.
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Speaker 1 (Anaemia #4)
Cosmophar,
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Speaker 1 (Anaemia #4)
Pharynget,
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Speaker 1 (Anaemia #4)
Ferrahim,
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Speaker 2 (Anaemia #4)
Minofa is ferric hydroxide,
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Speaker 1 (Anaemia #4)
sucrose.
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Speaker 2 (Anaemia #4)
Cosmophar is iron dextran.
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Speaker 1 (Anaemia #4)
Pharynget is ferric carboxyl,
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Speaker 1 (Anaemia #4)
maltose.
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Speaker 1 (Anaemia #4)
And Ferrahim is ferroxytol.
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Speaker 2 (Anaemia #4)
and the indication is chronic renal failure with erythropoietin
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Speaker 1 (Anaemia #4)
therapy.
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